N 6-Trimethyl-lysine metabolism. 3-Hydroxy-N6-trimethyl-lysine and carnitine biosynthesis
نویسندگان
چکیده
منابع مشابه
Biosynthesis of carnitine and 4-N-trimethylaminobutyrate from 6-N-trimethyl-lysine.
The conversion of 6-N-[Me-(14)C]trimethyl-lysine into carnitine and 4-N-trimethylaminobutyrate (butyrobetaine) was demonstrated in rats kept on a lysine-deficient diet. After the rats were given [(14)C]trimethyl-lysine for 4 days, a total of 17% of the injected label was recovered as carnitine from carcass and urine extracts. Another 8% of the trimethyl-lysine label was converted into 4-N-trime...
متن کاملBiosynthesis of carnitine and 4-N-trimethylaminobutyrate from lysine.
The conversion of l-[U-(14)C]lysine into carnitine was demonstrated in normal, choline-deficient and lysine-deficient rats. In other experiments in vivo radioactivity from l-[4,5-(3)H]lysine and dl-[6-(14)C]lysine was incorporated into carnitine; however, radioactivity from dl-[1-(14)C]lysine and dl-[2-(14)C]lysine was not incorporated. Administered l-[Me-(14)C]methionine labelled only the 4-N-...
متن کاملCarnitine Biosynthesis /3-HYDROXYLATION OF TRIMETHYLLYSINE BY AN a-KETOGLUTARATE-DEPENDENT MITOCHONDRIAL DIOXYGENASE*
Rat liver mitochondria were found to hydroxylate E-Ntrimethyl+lysine to produce P-hydroxy-c-N-trimethyl-L-lysine, an intermediate in carnitine biosynthesis. The hydroxylating system requires a-ketoglutarate, Fez+, and ascorbate, but does not require NADPH nor NADH. No activity was found in the microsomal or soluble fractions of liver extracts. The hydroxylated a-amino acid was isolated and char...
متن کاملCharacterization and properties of carnitine acyltransferases.
lysine metabolism has been measured in rats fed a diet low in trimethyl-lysine and carnitine (Davis & Hoppel, 1983, 1986). Under these steady-state conditions, the total body trimethyl-lysine content is similar to the total body carnitine content. The tissue distribution of peptide-linked and free trimethyl-lysine shows that approximately 68% of the total trimethyl-lysine is present in skeletal...
متن کاملRole of Lysine and s-NTrimethyllysine in Carnitine Biosynthesis
We have previously reported that weanling rats fed a 20% wheat gluten diet, limiting in lysine and containing no detectable carnitine, have significantly lower levels of carnitine in skeletal and heart muscle than rats receiving adequate dietary lysine. Rats on 20% wheat gluten diets were administered appropriate levels of DL-[6-i*C]lysine, L-[mefhyZ3H]methionine, t-N-[mefhyZ-3H]trimethyl-L-lys...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1980
ISSN: 0306-3283
DOI: 10.1042/bj1880509